Dogs can react differently to various active ingredients, and some health conditions may increase the likelihood of adverse reactions.
Permethrin and Pyrethrins: While often used in topical treatments and sprays for dogs, these ingredients can be toxic to cats.
Isoxazoline Class (e.g., afoxolaner, sarolaner, fluralaner, lotilaner): These oral treatments are effective against fleas and ticks, but the FDA has issued warnings due to reports of neurologic side effects, such as seizures, tremors, and ataxia, especially in dogs with a history of such conditions.
MDR-1 Gene Mutation Sensitivity: Certain breeds like Collies, Australian Shepherds, and Shetland Sheepdogs have a mutation affecting how they process medications.
Pregnant or Lactating Dogs: Many oral preventatives are not approved for use in pregnant or nursing dogs.
Fipronil: Found in products like Frontline, fipronil is generally safe but may cause skin irritation or hair loss at the application site.
Essential Oils (e.g., geraniol, peppermint, thyme oil): Marketed as 'natural' alternatives, these can still cause allergic reactions or toxicity, especially if applied undiluted or ingested.
Garlic and Brewer’s Yeast: While sometimes included in chewables as natural repellents, garlic can be toxic to dogs in large quantities.
Never use dog flea treatments on cats and vice versa.
Always follow the manufacturer's dosage and application instructions.
Avoid using multiple flea treatments simultaneously unless explicitly advised by a vet.