Our veterinarian panel rounded up their top choices for best flea and tick medications based on their clinical observations, effectiveness of the product on patients, safety, cost, and other contributing factors. When selecting the right flea and tick preventative for your pup, it’s important to chat with your vet first to determine what makes sense based on their age and health. Your vet can also help you find the best flea and tick preventative depending on your dog’s lifestyle and whether a capsule, chew, or topical preventative would be better suited. Some flea and tick options also offer additional benefits, such as protection against heartworms or hookworms. Flea and tick preventatives for dogs only work when given on time, and when following the manufacturer’s directions on dosing. So if you miss doses, or aren’t consistent with your flea and tick schedule, your pup is at higher risk. Our panel of vets relied on their clinical experience and real-world feedback to evaluate each product on a series on parameters including ease of application, which pests it targets, and effectiveness.