What is the best anxiety medication for dogs for car rides?

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Your veterinarian can prescribe an effective medication to prevent the nausea and vomiting associated with car sickness, if needed. It is best given ahead of travel, and it can be used several days in a row if needed. Strategies to de-stress dog road trips include: A Thundershirt® swaddles the dog like an infant is swaddled, and can reduce anxiety. A pheromone calming collar can help reduce anxiety. Medication prescribed by your veterinarian: trazodone, gabapentin, and alprazolam are sometimes used to reduce the anxiety that some dogs experience when traveling. Adaptil® pheromone wipes or spray can be used in the carrier to lower anxiety. Test the medication at home as a “dry run” ahead of your trip so you know how your dog reacts to the medication.